SAS Programmes

data sets - one explanatory variable
Normal distribution, identity link, log-logistic model, Eleanor's FCR data
Normal distribution, logit link, log-logistic model, Zocchi resistant data
Binomial distribution, logit link, logistic model, Neurotensin only data from Stokes et al
(Wadley's) Poisson distribution, Eleanor's FCR data
 

data sets - two explanator variables
Normal distribution, identity link, Finney model, Gerig similar compounds data- J. Chemical Ecology, 1989
Normal distribution, identity link, Finney model with modelling variance, Machado and Robinson data - Stats in Medicine, 1994
Normal after logit of percents, identity link, Finney model, Shelton's herbicide data - ASA proceedings, 1990
Binomial distribution, logit link, Finney model, Dawson's data - JABES, 2000
Binomial distribution, logit link, Finney model, Giltinan data - Applied Stats, 1988
Binomial distribution, logit link, Finney model, LePelly & Sullivan (1936) data from Greco et al, 1988
Binomial distribution, logit link, Finney model, Martin (1942) data from Greco et al, 1988

optimal design programmes
D-optimal design for LL2 model in IML with variance function graph
D-optimal design for Finney5 model and Gerig dataset in IML with var. func graph

Reading List -

Abdelbasit, K.M. and Plackett, R.L., 1982, Experimental Design for Joint Action, Biometrics, 38, 171-179.
Berenbaum, M.C., 1989, What is Synergy?, Pharmacological Reviews, 41, 93-141.
Brunden, M.N., Vidmar, T.J., and McKean, J.W., 1988, Drug Interaction and Lethality Analysis, Bata Raton, Fl: CRC Press.
Dawson, K.S., Carter Jr., W.H. and Gennings, C., 2000, A Statistical Test for Detecting and Characterizing Departures From
            Additivity in Drug/Chemical Combinations, J. Agric., Biol., and Environ. Statistics, 5, 3, 342-359.
Faessel, H.M., Slocum, H.K, Rustum, Y.M. and Greco, W.R., 1999, Folic Acid-Enhanced Synergy for the Combination of
           Trimetrexate Plus the Glycinamide Ribonecleotide Formyltransferase Inhibitor AG2034, Biochemical Pharmacology, 57, 567-77.
Finney, D.J., 1978, Statistical Methods in Biological Assay, 3rd edition, Charles Griffen & Company, London.
Gerig, T.M., Blum, U. and Meier, K., 1989, Statistical Analysis of the Joint Inhibitory Action of Similar Compounds, J. Chemical
            Ecology, 15, 10, 2403-2412.
Giltinan, D.M., Capizzi, T.P. and Malani, H., 1988, Diagnostic Tests for Similar Action of Two Compounds, Applied Statistics,
            37, 1, 39-50.
Gouws, Eleanor, Drug Resistance in Malaria Research - The Statistical Approach, 1995, Univ. Natal Pietermaritzburg Press.
Greco, W.R. and Lawrence, D.D., 1988, Assessment of the Degree of Drug Interaction Where the Response Variable is
            Discrete, ASA JSM Biopharmaceutical Section Proceedings, 226-231.
Greco, W.R. and Tung, Y., 1991, D-Optimal Experimental Designs for Quantifying Synergy, ASA JSM Biopharmaceutical
            Section Proceedings, 244-249.
Greco, W.R., Sutor, D.C., Parsons, J.C., Khinkis, L.A., Hsieh, L., Rao, S.R., Tung, Y., Currie, C.C. and Susice, R.  1994,
            Monte-Carlo Comparisons of Rival Experimental Designs for Two-Agent Combined-Action Studies, Canadian J. of
            Infectious Dis., 5 (suppl.), 51A-59A.
Greco, W.R., Bravo, G. and Parsons, J.C., 1995, The Search for Synergy: A Critical Review from a Response Surface Perspective,
           Pharmacological Reviews, 47, 2, 331-385.
Haines, L.M., Clarke, G.P.Y., Gouws, E. and Rosenberger, W.F., 2001, Optimal Design for the Testing of Anti-Malarial Drugs,
           mODa6 Proceedings, Physica, 119-126.
Hutchinson, C.M., McGiffen Jr., M.E., Ohr, H.D., Sims, J.J. and Becker, J.O., 2000, Efficacy of Methyl Iodide and Synergy with
            Chloropicrin for Control of Fungi, Pest Management Science, 56, 413-418.
Kelly, C. and Rice, J., 1990, Monotone Smoothing with Application to Dose-Response Curves and the Assessment of Synergism,
           Biometrics, 46, 1071-1085.
Khinkis, L.A. and Greco, W.R., 1993, Analytical Solution of the D-Optimal Design Problem for Studies of Drug Synergy, ASA
            JSM Biopharmaceutical Section Proceedings, 323-327.
Levasseur, L.M., Faessel, H., Slocum, H.K. and Greco, W.R., 1998, Implications for Clinical Pharmacodynamic Studies of the
            Statistical Characterization of an In Vitro Antiproliferation Assay, J. Pharmacokinetics and Biopharmaceutics, 26, 6, 717-733.
Machado, S.G. and Robinson, G.A., 1994, A Direct, General Approach Based on Isobolograms for Assessing the Joint Action of
            Drugs in Pre-Clinical Experiments, Statistics in Medicine, 13, 2289-2309.
Shelton, J.T., 1990, A Response Surface Methodology for Detecting Synergistic Herbicide Mixtures, Proceedings of the 1990 JSM.
Suehnel, J., Parallel Dose-Response Curves in Combination Experiments, 1998, Bulletin of Mathematical Biology, 60, 197-213.
Thompson, J., George, E.O., Poquette, C.A., Cheshire, P.J., Richmond, L.B., de Graff, S.S.N., Ma, M., Stewart, C.F. and Houghton,
            P.J., 1999, Clinical Cancer Research, 5, 3617-3631.